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The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa.
Abraham, Deepthi Raju; Butters, Claire; Abdulbari Yunis, Nurea; Lishman, Juanita; Scott, Christiaan; van der Zalm, Marieke M; Zühlke, Liesl; Rabie, Helena; Webb, Kate.
  • Abraham DR; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.
  • Butters C; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • Abdulbari Yunis N; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.
  • Lishman J; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.
  • Scott C; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • van der Zalm MM; Clinical Research Centre, University of Cape Town, Cape Town, South Africa.
  • Zühlke L; Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
  • Rabie H; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • Webb K; South African Medical Research Council, Cape Town, South Africa.
Pediatr Infect Dis J ; 41(12): e510-e512, 2022 Dec 01.
Article in English | MEDLINE | ID: covidwho-2029115
ABSTRACT
The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ancestral type, Beta, Delta, and Omicron) variant-driven waves and found that MIS-C remains a severe disease with a stable clinical presentation, regardless of variant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: INF.0000000000003691

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: INF.0000000000003691