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Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients.
Bajpai, Meenu; Maheshwari, Ashish; Kumar, Suresh; Chhabra, Karan; Kale, Pratibha; Narayanan, Ashad; Gupta, Amita; Gupta, Ekta; Trehanpati, Nirupama; Agarwal, Reshu; Gupta, Kamini; Bhardwaj, Ankit; Islam, Mojahidul; Singh, Ravinder; Yadav, Pushpa; Kumar, Guresh; Sarin, Shiv K.
  • Bajpai M; Institute of Liver and Biliary Sciences, Department of Transfusion Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Maheshwari A; Institute of Liver and Biliary Sciences, Department of Transfusion Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Kumar S; Lok Nayak Jai Prakash Hospital, Department of Medicine, J6QP+PRR, Jawaharlal Nehru Marg, Maulana Azad Medical College Campus, Delhi Gate, 110002 New Delhi, Delhi, India.
  • Chhabra K; Lok Nayak Jai Prakash Hospital, Department of Medicine, J6QP+PRR, Jawaharlal Nehru Marg, Maulana Azad Medical College Campus, Delhi Gate, 110002 New Delhi, Delhi, India.
  • Kale P; Institute of Liver and Biliary Sciences, Department of Microbiology, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Narayanan A; Institute of Liver and Biliary Sciences, Department of Hepatology, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Gupta A; Institute of Liver and Biliary Sciences, Department of Transfusion Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Gupta E; Institute of Liver and Biliary Sciences, Department of Molecular and Cellular Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Trehanpati N; Institute of Liver and Biliary Sciences, Department of Molecular and Cellular Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Agarwal R; Institute of Liver and Biliary Sciences,Department of HepatoVirology, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Gupta K; Institute of Liver and Biliary Sciences,Department of HepatoVirology, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Bhardwaj A; Institute of Liver and Biliary Sciences, Department of Clinical Research, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Islam M; Institute of Liver and Biliary Sciences, Department of Molecular and Cellular Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Singh R; Institute of Liver and Biliary Sciences, Department of Molecular and Cellular Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Yadav P; Institute of Liver and Biliary Sciences, Department of Molecular and Cellular Medicine, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Kumar G; Institute of Liver and Biliary Sciences, Department of Research, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
  • Sarin SK; Institute of Liver and Biliary Sciences, Department of Hepatology, D1 ilbs, D-1, Vasant Kunj Rd, Ghitorni, 110070 New Delhi, Delhi, India.
An Acad Bras Cienc ; 94(4): e20210202, 2022.
Article in English | MEDLINE | ID: covidwho-2029823
ABSTRACT

BACKGROUND:

Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients.

METHODS:

One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease.

RESULTS:

The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: An Acad Bras Cienc Year: 2022 Document Type: Article Affiliation country: 0001-3765202220210202

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: An Acad Bras Cienc Year: 2022 Document Type: Article Affiliation country: 0001-3765202220210202