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Exploration of PDCoV-induced apoptosis through mitochondrial dynamics imbalance and the antagonistic effect of SeNPs.
Ren, Zhihua; Yu, Yueru; Zhang, Xiaojie; Wang, Qiuxiang; Deng, Junliang; Chen, Chaoxi; Shi, Riyi; Wei, Zhanyong; Hu, Hui.
  • Ren Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  • Yu Y; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  • Zhang X; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  • Wang Q; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  • Deng J; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  • Chen C; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  • Shi R; College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, China.
  • Wei Z; Department of Basic Medical Sciences, College of Veterinary Medicine, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
  • Hu H; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Front Immunol ; 13: 972499, 2022.
Article in English | MEDLINE | ID: covidwho-2029965
ABSTRACT
Porcine Deltacoronavirus (PDCoV), an enveloped positive-strand RNA virus that causes respiratory and gastrointestinal diseases, is widely spread worldwide, but there is no effective drug or vaccine against it. This study investigated the optimal Selenium Nano-Particles (SeNPs) addition concentration (2 - 10 µg/mL) and the mechanism of PDCoV effect on ST (Swine Testis) cell apoptosis, the antagonistic effect of SeNPs on PDCoV. The results indicated that 4 µg/mL SeNPs significantly decreased PDCoV replication on ST cells. SeNPs relieved PDCoV-induced mitochondrial division and antagonized PDCoV-induced apoptosis via decreasing Cyt C release and Caspase 9 and Caspase 3 activation. The above results provided an idea and experimental basis associated with anti-PDCoV drug development and clinical use.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Selenium / Swine Diseases / Coronavirus Infections / Coronavirus Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.972499

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Selenium / Swine Diseases / Coronavirus Infections / Coronavirus Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.972499