Phylogeography and genomic analysis of SARS-CoV-2 delta variant in Morocco.
J Infect Dev Ctries
; 16(8): 1258-1268, 2022 08 30.
Article
in English
| MEDLINE | ID: covidwho-2030105
ABSTRACT
INTRODUCTION:
Since the COVID-19 pandemic began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously evolved with many variants of concern emerging across the world.METHODOLOGY:
In order to monitor the evolution of these variants in Morocco, we analyzed a total of 2130 genomes of the delta variant circulating around the world. We also included 164 Moroccan delta variant sequences in our analysis.RESULTS:
Our findings suggest at least four introductions from multiple international sources and a rise of a dominant delta sub-lineage AY.33 in Morocco. Moreover, we report three mutations in the N-terminal domain of the S protein specific to the Moroccan AY.33 isolates, T29A, T250I and T299I. The effect of these mutations on the secondary structure and the dynamic behavior of the S protein N-terminal domain was further determined.CONCLUSIONS:
We conclude that these mutations might have functional consequences on the S protein of SARS-CoV-2.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
Topics:
Variants
Limits:
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
J Infect Dev Ctries
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
Affiliation country:
Jidc.16513
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