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Biomimetic fabrication of nanotherapeutics by leukocyte membrane cloaking for targeted therapy.
Mohale, Samyak; Kunde, Shalvi Sinai; Wairkar, Sarika.
  • Mohale S; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
  • Kunde SS; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
  • Wairkar S; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India. Electronic address: sarikawairkar@gmail.com.
Colloids Surf B Biointerfaces ; 219: 112803, 2022 Aug 24.
Article in English | MEDLINE | ID: covidwho-2031218
ABSTRACT
Cell membrane cloaking is an important biomimetic approach for improving drug residence time in the body due to its distinctive concealment ability, making it highly biocompatible and efficient for targeted drug delivery. Leukocytes are considered a fundamental part of the immune system. Leukocyte membrane cloaked nanoparticles offer site-specificity and can escape the opsonization process besides enhanced systemic circulation time. This review emphasizes the anatomical and physiological features of different leukocytes in addition to the preparation and characterization of leukocyte membrane cloaked nanoparticles. It also covers the recent advancements of this biointerfacing platform in cancer therapy, inflammatory disorders, multifunctional targeted therapy and hybrid membrane-coated nanoparticles. However, leukocytes are complex, nucleated cell structures and isolating their membranes poses a greater difficulty. Leukocyte membrane cloaking is an upcoming strategy in the infancy stage; nevertheless, there is immense scope to explore this biomimetic delivery system in terms of clinical transition, particularly for inflammatory diseases and cancer.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Colloids Surf B Biointerfaces Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: J.colsurfb.2022.112803

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Colloids Surf B Biointerfaces Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: J.colsurfb.2022.112803