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What are the prospects for durable immune control?
Lelievre, J D; Bauer, J.
  • Lelievre JD; Immunologie clinique et maladies infectieuses, Hôpital Henri-Mondor, 94000 Créteil, France.
  • Bauer J; Service Universitaire des Maladies Infectieuses et du Voyageurs, CH Dron, 59200 Tourcoing, France. Electronic address: bauerjules@gmail.com.
Infect Dis Now ; 52(8S): S4-S6, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2268429
ABSTRACT
During the SARS CoV-2 primary infection, the neutralizing antibodies focused against the spike (S) glycoproteins are responsible for blockage of virus-host cell interaction. The cellular response mediated by CD4+ and CD8+ T-cells is responsible for control of viremia. Immune memory against SARS-CoV-2 depends on virus type, replication kinetics and route of penetration. The formation and persistence of germinal centers are critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating durable immunity. They can persist up to 30 weeks after vaccination and several months after infection. Heterogeneity in the longevity of the vaccination-induced GC response is significant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Envelope Proteins / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Infect Dis Now Year: 2022 Document Type: Article Affiliation country: J.idnow.2022.09.010

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Envelope Proteins / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Infect Dis Now Year: 2022 Document Type: Article Affiliation country: J.idnow.2022.09.010