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Mortality in patients with pemphigus: a retrospective US claims database study
Journal of the American Academy of Dermatology ; 87(3):AB83, 2022.
Article in English | EMBASE | ID: covidwho-2031381
ABSTRACT

Objective:

We evaluated mortality in patients with pemphigus compared with nonpemphigus individuals matched on age and gender, in the United States (US).

Methods:

This retrospective cohort study used data from the US Optum Clinformatics claims database between May 1, 2000 and December 31, 2020. Mortality was assessed during a follow-up of up to 4 years after the index date (first pemphigus diagnosis). A sensitivity analysis was conducted (end of study period, March 31, 2020) to exclude the potential impact of COVID-19 on mortality analysis. Multivariable models (comorbidities as adjustment variables) were used to assess hazard ratios (HRs). Propensity score matched (PSM) model was used to minimize comorbidities difference at baseline.

Results:

Overall, 1391 patients with pemphigus (ICD-9 and ICD-10 codes) were identified (mean [SD] age 63.7 [17.9] years;females 57.0%). During follow-up, 227 patients (16.3%) died in the pemphigus cohort, compared with 172 patients (12.4%) in the nonpemphigus cohort. Pemphigus patients had higher death rate than the nonpemphigus cohort (adjusted HR [95% CI] 1.69 [1.37–2.09];unadjusted HR [95% CI] 1.33 [1.09–1.63];PSM HR [95% CI] 1.49 [1.19–1.86];P <.01 for all). Similar results were observed in the sensitivity analysis (adjusted HR [95% CI] 1.77 [1.41–2.23];P <.01);PSM HR [95% CI] 1.52 [1.20–1.93];P <.01]). Infections, hypertension, diabetes, hematologic abnormalities, and cardiovascular comorbidities were strongly associated with mortality in pemphigus patients.

Conclusions:

These results suggest that pemphigus is associated with increased mortality observed over 4 years, highlighting the need for better treatment options for these patients.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Language: English Journal: Journal of the American Academy of Dermatology Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Language: English Journal: Journal of the American Academy of Dermatology Year: 2022 Document Type: Article