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The pathogenicity of COVID-19 and the role of pentraxin-3: An updated review study.
Margiana, Ria; Sharma, Satish Kumar; Khan, Bilal Irshad; Alameri, Ameer A; Opulencia, Maria Jade Catalan; Hammid, Ali Thaeer; Hamza, Thulfeqar Ahmed; Babakulov, Sharaf Khamrakulovich; Abdelbasset, Walid Kamal; Jawhar, Zanko Hassan.
  • Margiana R; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Acade
  • Sharma SK; Department of Pharmacology, Glocal School of Pharmacy, The Glocal University, Saharanpur, India. Electronic address: satishdipsar55@gmail.com.
  • Khan BI; Mbbs, Rawalpindi Medical University, Rawalpindi, Pakistan.
  • Alameri AA; Department of Chemistry, University of Babylon, Iraq.
  • Opulencia MJC; College of Business Administration, Ajman University, Ajman, United Arab Emirates.
  • Hammid AT; Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.
  • Hamza TA; Medical laboratory techniques department, Al-Mustaqbal University College, Babylon, Iraq.
  • Babakulov SK; Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent 100047, Uzbekistan; Research scholar, Department of Scientific affairs, Samarkand State Medical Institute, Amir Temur Street 18, Samarkand, Uzbekistan.
  • Abdelbasset WK; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
  • Jawhar ZH; Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Kurdistan Region, Iraq.
Pathol Res Pract ; 238: 154128, 2022 Sep 15.
Article in English | MEDLINE | ID: covidwho-2031630
ABSTRACT
In recent years, the COVID-19 pandemic has become one of the most crucial scientific issues in the world, and efforts to eradicate the disease are still ongoing. The acute inflammatory reaction associated with this disease is associated with several complications such as cytokine storm, multiple organ damage, lung fibrosis, and blood clots. PTX3, as part of the humoral innate immune systems, is one of the acute-phase proteins that perform various functions, such as modulating inflammation, repairing tissue, and recruiting immune cells. PTX3 is increased in people with SARS-CoV-2, and its level decreases with proper treatment. Therefore, it can be regarded as a suitable marker for the prognosis of the COVID-19 and evaluating the effectiveness of the treatment method applied. However, some studies have shown that PTX3 can be a double-edged sword and develop tumors by providing an immunosuppressive environment.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article