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SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis.
Mozaffari, Shahrooz Amin; Salehi, Ali; Mousavi, Elnaz; Zaman, Burhan Abdullah; Nassaj, Ali Eslambol; Ebrahimzadeh, Farnoosh; Nasiri, Hadi; Valedkarimi, Zahra; Adili, Ali; Asemani, Ghazaleh; Akbari, Morteza.
  • Mozaffari SA; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
  • Salehi A; Department of Oral and Maxillofacial Radiology, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Islamic Republic of Iran.
  • Mousavi E; Dental Sciences Research Center, Department of Endodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Islamic Republic of Iran.
  • Zaman BA; Department of Basic Sciences, College of Pharmacy, University of Duhok, Duhok, Kurdistan Region, Iraq.
  • Nassaj AE; Department of Endodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
  • Ebrahimzadeh F; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
  • Nasiri H; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
  • Valedkarimi Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
  • Adili A; Senior Adult Oncology Department, Moffitt Cancer Center, University of South Florida, Tampa, USA; Department of Oncology, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
  • Asemani G; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
  • Akbari M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran. Electronic address: akbarimo@tbzmed.ac.ir.
Pathol Res Pract ; 239: 154131, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2031631
ABSTRACT
The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global pandemic with more than 170 million confirmed infections and more than 6 million deaths (by July 2022). Studies have shown that infection with SARS-CoV-2 in cancer patients has a higher mortality rate than in people without cancer. Here, we have reviewed the evidence showing that gut microbiota plays an important role in health and is linked to colorectal cancer development. Studies have shown that SARS-CoV-2 infection leads to a change in gut microbiota, which modify intestinal inflammation and barrier permeability and affects tumor-suppressor or oncogene genes, proposing SARS-CoV-2 as a potential contributor to CRC pathogenesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Colorectal Neoplasms / Gastrointestinal Microbiome / COVID-19 Limits: Humans Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Colorectal Neoplasms / Gastrointestinal Microbiome / COVID-19 Limits: Humans Language: English Journal: Pathol Res Pract Year: 2022 Document Type: Article