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Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine.
Tang, Bo; Tang, Li; He, Wei; Jiang, Xingyu; Hu, Changjiang; Li, Yicheng; Zhang, Yang; Pang, Kun; Lei, Yuanyuan; Li, Shengpeng; Liu, Shuang; Wang, Sumin; Yang, Min; Li, Zhongjun; Zhao, Fangqing; Yang, Shiming.
  • Tang B; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Tang L; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • He W; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Jiang X; Laboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Hu C; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Li Y; Laboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Zhang Y; Laboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Pang K; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
  • Lei Y; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Li S; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Liu S; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Wang S; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Yang M; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
  • Li Z; Laboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: johnneyusc@gmail.com.
  • Zhao F; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: zhfq@biols.ac.cn.
  • Yang S; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: yangshiming@tmmu.edu.cn.
Cell Rep Med ; 3(10): 100752, 2022 10 18.
Article in English | MEDLINE | ID: covidwho-2031746
ABSTRACT
Increasing evidence indicates that gut microbiota may play a key role in vaccination immunity. Here, we investigate whether the human gut microbiota and metabolic function correlate with the BBIBP-CorV vaccine response. A total of 207 participants who received the BBIBP-CorV vaccine are enrolled. The gut microbiome and metabolic functions are investigated using metagenomic sequencing and metabolomic assays. We find that BBIBP-CorV vaccination is accompanied by altered microbiome composition and functional pathways, and the gut microbiome and its functional profiles correlate with the vaccine response. The levels of short-chain fatty acids (SCFAs) are much higher in the high antibody response group compared to the low response group, and several SCFAs display a positive correlation with the antibody response. Our study highlights that the gut microbiome and its function is associated with the BBIBP-CorV vaccine response, providing evidence for further exploration of microbiome modulation to improve COVID-19 vaccine efficacy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100752

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100752