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High sensitivity detection of SARS-CoV-2 by an optofluidic hollow eccentric core fiber.
Tan, Qin; Wu, Shengnan; Liu, Zhenchao; Wu, Xun; Forsberg, Erik; He, Sailing.
  • Tan Q; Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China.
  • Wu S; Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China.
  • Liu Z; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
  • Wu X; Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China.
  • Forsberg E; Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China.
  • He S; Centre for Optical and Electromagnetic Research, National Engineering Research Center for Optical Instruments, Zhejiang University, Hangzhou 310058, China.
Biomed Opt Express ; 13(9): 4592-4605, 2022 Sep 01.
Article in English | MEDLINE | ID: covidwho-2283459
ABSTRACT
Since the outbreak of coronavirus disease 2019 (COVID-19), efficient real-time monitoring has become one of the challenges faced in SARS-CoV-2 virus detection. A compact all-fiber Mach-Zehnder interferometer optofluidic sensor based on a hollow eccentric core fiber (HECF) for the detection and real-time monitoring of SARS-CoV-2 spike glycoprotein (SARS-CoV-2 S2) is proposed, analyzed and demonstrated. The sensor is comprised of fusion splicing single mode fiber (SMF), hollow core fiber (HCF) and HECF. After the incident light passes through the HCF from the SMF, it uniformly enters the air hole and the suspended micrometer-scale fiber core of the HECF to form a compact all-fiber Mach-Zehnder interferometer (MZI). HECF is side polished to remove part of the cladding that the suspended fiber core can contact the external environment. Subsequently, the mouse anti SARS-CoV-2 S2 antibody is fixed on the surface of the suspended-core for the sake of achieving high sensitivity and specific sensing of SARS-CoV-2 S2. The limit of detection (LOD) of the sensor is 26.8 pM. The proposed sensor has high sensitivity, satisfactory selectivity, and can be fabricated at low cost making it highly suitable for point-of-care testing and high-throughput detection of early stage of COVID-19 infection.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Biomed Opt Express Year: 2022 Document Type: Article Affiliation country: BOE.465136

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Journal: Biomed Opt Express Year: 2022 Document Type: Article Affiliation country: BOE.465136