Your browser doesn't support javascript.
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Wang, Kang; Tang, Yan; Wu, Xiu; Liang, Hongmin; Chen, Daiwen; Yu, Bing; He, Jun; Mao, Xiangbing; Huang, Zhiqing; Yan, Hui; Wu, Aimin; Luo, Yuheng; Zheng, Ping; Yu, Jie; Wang, Huifen; Luo, Junqiu.
  • Wang K; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Tang Y; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Wu X; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Liang H; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Chen D; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Yu B; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • He J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Mao X; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Huang Z; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Yan H; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Wu A; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Luo Y; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Zheng P; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Yu J; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
  • Wang H; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
  • Luo J; Key Laboratory of Animal Disease-Resistant Nutrition, Chengdu 611130, China.
Antioxidants (Basel) ; 11(9)2022 Sep 18.
Article in English | MEDLINE | ID: covidwho-2032830
ABSTRACT
Transmissible gastroenteritis virus (TGEV), a coronavirus that causes severe diarrhea due to oxidative stress in the piglet intestine, is a major cause of economic loss in the livestock industry. However, limited interventions have been shown to be effective in the treatment of TGEV. Here, we demonstrate the therapeutic activity of eugenol in TGEV-induced intestinal oxidative stress and apoptosis. Our data show that eugenol supplementation protects intestine and IPEC-J2 cells from TGEV-induced damage. Mechanistically, eugenol reduces TGEV-induced oxidative stress in intestinal epithelial cells by reducing reactive oxygen species levels. Interestingly, eugenol also inhibits TGEV-induced intestinal cell apoptosis in vitro and in vivo. In conclusion, our data suggest that eugenol prevents TGEV-induced intestinal oxidative stress by reducing ROS-mediated damage to antioxidant signaling pathways. Therefore, eugenol may be a promising therapeutic strategy for TGEV infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Antiox11091838

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Antiox11091838