Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases.
Int J Environ Res Public Health
; 19(18)2022 Sep 11.
Article
in English
| MEDLINE | ID: covidwho-2032943
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease causing systemic thrombotic microangiopathy (TMA) due to the fact of complement dysregulation. Immune activation by viruses, including SARS-CoV-2, can lead to the development of an episode of aHUS against a background of genetic dysregulation in the complement pathway. This paper presents an analysis of two cases of aHUS-siblings diagnosed with familial disease, with a genetic predisposition to aHUS, in whom infection with SARS-CoV-2 was a strong trigger of disease recurrence. The quick recognition and treatment with eculizumab in the early stage of the disease resulted in a rapid improvement in clinical conditions and laboratory parameters.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Atypical Hemolytic Uremic Syndrome
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijerph191811437
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