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Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque.
Nawaz, Muhammad; Ashraf, Muhammad Adnan; Ali, Muhammad Asad; Shabbir, Muhammad Zubair; Shabbir, Muhammad Abu Bakr; Altaf, Imran; Raza, Sohail; Rafique, Saira; Hassan, Sohail; Sardar, Nageen; Mehmood, Adnan; Aziz, Muhammad Waqar; Fazal, Sehar; Khan, Muhammad Tahir; Atique, Hafiz Muhammad Moavia; Asif, Ali; Ullah, Zia; Iqbal, Mubashir; Imtiaz, Talha; Anwar, Muhammad; Mukhtar, Nadia; Yaqub, Tahir.
  • Nawaz M; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Ashraf MA; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Ali MA; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Shabbir MZ; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Shabbir MAB; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Altaf I; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Raza S; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Rafique S; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Hassan S; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Sardar N; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Mehmood A; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Aziz MW; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Fazal S; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Khan MT; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Atique HMM; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Asif A; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Ullah Z; Pet Centre, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Iqbal M; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Imtiaz T; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Anwar M; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Mukhtar N; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
  • Yaqub T; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Life (Basel) ; 12(9)2022 Sep 13.
Article in English | MEDLINE | ID: covidwho-2033051
ABSTRACT
Iodine complexes have known antimicrobial properties along with reported in-vitro antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in Rhesus macaque. Rhesus macaque were assigned to A) prophylactic group (n = 3), (B) treatment group (n = 3), (C) infection control group (n = 4), and (D) negative control group (n = 4). Groups A, B, and C were challenged with 2 × 106 TCID of SARS-CoV-2. The prophylactic group (A) was administered Renessans from 5 days before infection till 8 days postinfection (DPI). The treatment group (B) was administered Renessans from 3 till 8 DPI. Group C was administered water-insoluble fractions only. Nasal swabs from all monkeys of groups A, B, and C remained positive for SARS-CoV-2 till 2 and 7 DPI, while the swabs became negative for groups A and B at 14 DPI. Likewise, fecal matter of monkeys in group A returned negative results during the experiment, while that of group B had significantly decreased viral load (101.5 genome copies/mL) compared to group C (103 genome copies/mL). Hence, it is concluded that Renessans has in-vivo SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Life12091424

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Life12091424