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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach.
Wyman, Kailey A; Girgis, Adel S; Surapaneni, Pragnakiran S; Moore, Jade M; Abo Shama, Noura M; Mahmoud, Sara H; Mostafa, Ahmed; Barghash, Reham F; Juan, Zou; Dobaria, Radha D; Almalki, Ahmad J; Ibrahim, Tarek S; Panda, Siva S.
  • Wyman KA; Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
  • Girgis AS; Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.
  • Surapaneni PS; Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
  • Moore JM; Schulich School of Medicine and Dentistry, Western University, London, ON N6A5C1.1, Canada.
  • Abo Shama NM; Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
  • Mahmoud SH; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
  • Mostafa A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
  • Barghash RF; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
  • Juan Z; Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.
  • Dobaria RD; Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
  • Almalki AJ; Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
  • Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Panda SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Molecules ; 27(18)2022 Sep 12.
Article in English | MEDLINE | ID: covidwho-2033063
ABSTRACT
We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates' selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27185923

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Molecules27185923