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Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
Amblard, Franck; LeCher, Julia C; De, Ramyani; Goh, Shu Ling; Li, Chengwei; Kasthuri, Mahesh; Biteau, Nicolas; Zhou, Longhu; Tber, Zahira; Downs-Bowen, Jessica; Zandi, Keivan; Schinazi, Raymond F.
  • Amblard F; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • LeCher JC; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • De R; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Goh SL; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Li C; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Kasthuri M; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Biteau N; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Zhou L; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Tber Z; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Downs-Bowen J; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Zandi K; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
  • Schinazi RF; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Pharmaceuticals (Basel) ; 15(9)2022 Sep 14.
Article in English | MEDLINE | ID: covidwho-2033081
ABSTRACT
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of N4-hydroxycytidine (NHC), was recently emergency-use approved for the treatment of early SARS-CoV-2 infections. Herein, we report the synthesis and evaluation of a series of novel NHC analogs.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Year: 2022 Document Type: Article Affiliation country: Ph15091144

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Year: 2022 Document Type: Article Affiliation country: Ph15091144