Donepezil Beyond Alzheimer’s Disease? A Narrative Review of Therapeutic Potentials of Donepezil in Different Diseases
Iranian Journal of Pharmaceutical Research
; 21(1), 2022.
Article
in English
| EMBASE | ID: covidwho-2033387
ABSTRACT
Donepezil hydrochloride is an acetylcholine esterase inhibitor studied and approved to treat Alzheimer’s disease (AD). However, this drug can have positive therapeutic potential in treating different conditions, including various neurodegenerative disorders such as other types of dementia, multiple sclerosis, Parkinson’s disease, psychiatric and mood disorders, and even infectious diseases. Hence, this study reviewed the therapeutic potential of this drug in treating Alzheimer’s and other diseases by reviewing the articles from databases including Web of Science, Scopus, PubMed, Cochrane, and Science Direct. It was shown that donepezil could affect the pathophysiology of these diseases via mechanisms such as increasing the concentration of acetylcholine, modulating local and systemic inflammatory processes, affecting acetylcholine receptors like nicotinic and muscarinic receptors, and activating various cellular signaling via receptors like sigma-1 receptors. Despite many therapeutic potentials, this drug has not yet been approved for treating non-Alzheimer’s diseases, and more comprehensive studies are needed.
acetylcholine; acetylcholinesterase; amyloid precursor protein; brain derived neurotrophic factor; cholinergic receptor; donepezil; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; mitogen activated protein kinase; muscarinic receptor; nicotinic acid derivative; nicotinic receptor; phosphatidylinositol 3 kinase; prostaglandin E2; protein kinase B; sigma 1 opiate receptor; tumor necrosis factor; Akt signaling; Alzheimer disease; antidepressant activity; autism; brain blood flow; brain depth stimulation; Cochrane Library; cognitive defect; coronavirus disease 2019; degenerative disease; dementia; depression; dorsomedial striatum; endoplasmic reticulum stress; gene expression; human; immune response; immune system; inflammation; innate immunity; leukocyte; Medline; memory disorder; mental disease; mood disorder; multiple sclerosis; nerve degeneration; nervous system development; neuropsychological test; noradrenergic system; nuclear reprogramming; Parkinson disease; review; risk factor; schizophrenia; ScienceDirect; Scopus; search engine; signal transduction; sleep disorder; social interaction; systematic review; traumatic brain injury; visual memory; Web of Science; working memory
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
Language:
English
Journal:
Iranian Journal of Pharmaceutical Research
Year:
2022
Document Type:
Article
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