Analysis of applicable pattern and mechanism of medicine and food homologous traditional Chinese medicine in prevention and treatment of modern viral infectious diseases
Chinese Traditional and Herbal Drugs
; 53(15):4781-4794, 2022.
Article
in Chinese
| EMBASE | ID: covidwho-2033401
ABSTRACT
Objective To explore the application pattern and mechanism of medicine and food homologous traditional Chinese medicine (TCM) against modern viral diseases. Methods The method of literature mining was applied based on the characteristics of modern viral diseases, combining with ancient books and modern prescriptions for the prevention and treatment of viral diseases to build a relevant prescription database. Then SPSS and R language were used to analyze the high-frequency medicine and food homologous TCM and high confidence medicine and food homologous prescriptions in these prescriptions, and cluster analysis was carried out. The antiviral characteristic active ingredients of high-frequency medicinal and food homologous TCN were identified and analyzed, and the action mechanism of active ingredients against modern viral diseases was evaluate by network pharmacology. Results In the prevention and treatment of modern viral diseases, Gancao (Glycyrrhizae Radix et Rhizoma)-Chenpi (Citri Reticulatae Pericarpium)-Fuling (Poria) had the highest confidence, Glycyrrhizae Radix et Rhizoma-Jiegeng (Platycodonis Radix) had the highest support. At the same time, the prescriptions were clustered and analyzed to obtain Jinyinhua (Lonicerae Japonicae Flos)-Huangqi (Astragali Radix)-Huoxiang (Agastache rugosa), Glycyrrhizae Radix et Rhizoma-Xingren (Armeniacae Semen Amarum)-Poria-Platycodonis Radix-Citri Reticulatae Pericarpium, Ganjiang (Zingiberis Rhizoma)-Renshen (Ginseng Radix et Rhizoma), Zisu (Perilla frutescens)-Gegen (Puerariae Lobatae Radix), Lugen (Phragmitis Rhizoma)-Sangye (Mori Folium), Shengjiang (Zingiberis Rhizoma Recens)-Dazao (Jujubae Fructus) clustering new prescription. The core action targets of EGFR, CASP3, VEGFA, STAT3, MMP9, HSP90AA1, mTOR, PTGS2, MMP2, TLR4, MAPK14, etc were identified. The action mechanism involved human cytomegalovirus infection, coronavirus disease-coronavirus disease 2019 (COVID-19), etc. The core action pathway were phosphatidylinositol-3/kinase protein kinase B (PI3K/Akt) signal pathway, mitogen activated protein kinase (MAPK) signal pathway, interleukin-17 (IL-17) signal pathway, Janus kinase/signal transducer and activator of transcription (JAK/STAT) signal pathway, etc. Conclusion Through data mining, six new prescriptions for preventing and controlling modern viral diseases were obtained, and the mechanism of action was preliminarily discussed, which provided some reference for the research and development of medicine and food homologous TCM prescriptions for the prevention and treatment of viral epidemics and related health products.
Agastache rugosa; article; Chinese medicine; cluster analysis; coronavirus disease 2019; data analysis software; data mining; epidemic; fruit; ginseng; human; Human cytomegalovirus; language; nonhuman; Perilla frutescens; Poria; prescription; rhizome; seminal plasma; signal transduction; systems pharmacology; antivirus agent; Astragalus root; caspase 3; chenpi; cyclooxygenase 2; endogenous compound; epidermal growth factor receptor; gelatinase B; ginger extract; Glycyrrhiza uralensis root; glycyrrhizae radix; heat shock protein 90 alpha; interleukin 17; Janus kinase; Lonicera extract; Lonicera japonica extract; mammalian target of rapamycin; mitogen activated protein kinase; mitogen activated protein kinase 14; mulberry extract; phosphatidylinositol 3 kinase; Platycodon grandiflorum extract; protein kinase B; STAT protein; STAT3 protein; toll like receptor 4; unclassified drug; vasculotropin A
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Traditional medicine
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2022
Document Type:
Article
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