COVID-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study
Acta Medica Iranica
; 60(6):329-337, 2022.
Article
in English
| EMBASE | ID: covidwho-2033504
ABSTRACT
Solid-organ transplantation recipients were assumed highly vulnerable to coronavirus disease 2019 (COVID-19). However, the results of previous studies in patients with orthotopic heart transplantation (OHT) under immunosuppressive therapy are contradictory. Therefore, we aimed to assess the prevalence of COVID-19 infection and associated risk factors, along with the six-month outcomes in COVID-19 positive OHT patients. This single-center telephone-based survey was conducted on OHT patients. Using a detailed questionnaire, exposure to COVID-19, related symptoms, and preventive self-care measures were collected. Outcomes of COVID-19-positive patients were reassessed using another survey six months later. 118 OHT patients (male n=87, 73.7%) were included with a mean age of 45.3±13.1 years. Sixteen patients (13.5%) reported one or more symptoms compatible with COVID-19, of whom 12 (10.2%) tested positive. Our results indicated no statistically significant association between COVID-19 and comorbidities. Poor adherence to self-care measures and contact with positive index cases were both significantly associated with COVID-19 infection (P<0.001). A later six months follow-up showed that two out of 12 (16.6%) COVID-19 positive OHT patients died. There was no statistically significant difference between the prevalence of COVID-19 in our patients compared to Iran’s general population (P=251.0). Non-compliance with personal protective protocols and a history of contact with COVID-19 cases were the most risk factors for COVID-19 infection in OHT patients.
telephone; cyclosporine; isoniazid; mycophenolate mofetil; prednisolone; prednisone; tacrolimus; abdominal pain; adult; anosmia; article; asthma; cardiac graft rejection; cardiovascular risk; chronic obstructive lung disease; comorbidity; controlled study; coronary artery bypass graft; coronavirus disease 2019; cross-sectional study; dyspnea; echocardiography; electrocardiography; enzyme linked immunosorbent assay; female; fever; follow up; graft recipient; health survey; heart graft; heart left ventricle ejection fraction; heart transplantation; hospitalization; human; hypertension; immunosuppressive treatment; intensive care unit; lung artery pressure; major clinical study; male; medication compliance; middle aged; myalgia; off pump coronary surgery; organ transplantation; outcome assessment; prevalence; prospective study; pulmonary hypertension; questionnaire; risk factor; self care; telephone interview; thorax radiography
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Acta Medica Iranica
Year:
2022
Document Type:
Article
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