The Occurrence and the Characteristics of Liver Injury, and its Impactamong Hospitalized Covid-19 Patients in Basrah City-Iraq
Indian Journal of Forensic Medicine and Toxicology
; 16(3):165-172, 2022.
Article
in English
| EMBASE | ID: covidwho-2033602
ABSTRACT
Background:
The respiratory system is most affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). However, COVID-19 can appear in a variety of ways. It has found a link between higher liver enzymes and COVID-19 infection, implying that the virus can induce liver damage through direct hepatotoxic injury, medication toxicity, or an immune-mediated response. Materials andMethods:
In the southern Iraqi province of Basra, a cross-sectional observational study is being conducted in a single center (Basra teaching hospital) to estimate the prevalence of liver damage among hospitalized patients and identify those at risk.Results:
The study found that most of the patients have a normal liver function test at the time of diagnosis and or admission, but after hospitalization, there is a statistically significant increase in the liver enzymes that is positively related to the disease severity and cytokine storm and also lead to more extended hospital staying and further mortality. Fortunately, the degree of liver damage is of mild severity in the majority of patients. Still, the severe form of liver damage was also noticed in some patients, especially those with a higher degree of lung involvement and severely desaturates with raised inflammatory markers.Conclusions:
Elevated liver enzymes are prevalent, but the majority is mild with COVID-19 disease. Liver function abnormalities, particularly increased levels of AST and ALT, are not only common in COVID-19, but they are also linked to poor outcomes, mainly if severe liver damage has occurred.
adult; alanine aminotransferase blood level; article; aspartate aminotransferase level; controlled study; coronavirus disease 2019; cytokine storm; female; hospital patient; hospitalization; human; hypertransaminasemia; Iraq; liver function; liver function test; liver injury; lung; male; mortality; observational study; outcome assessment; prevalence; risk assessment; teaching hospital; liver enzyme
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
English
Journal:
Indian Journal of Forensic Medicine and Toxicology
Year:
2022
Document Type:
Article
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