Characteristics of SARS - CoV - 2 nucleic acids and serum antibodies in different clinical specimens and their correlation with the course of COVID -19
Chinese Journal of Virology
; 36(6):997-1003, 2020.
Article
in Chinese
| GIM | ID: covidwho-2034152
ABSTRACT
To investigate the characteristics of the nucleic acids of severe acute respiratory syndrome coronavirus (SARS-CoV) -2 and antibodies in different specimens obtained from coronavirus disease 2019 (COVID-19) patients;if a correlation between these parameters and the disease course was present. The throat swabs and stool samples of 39 COVID-19 patients admitted to our hospital were collected in this study. Real-time reverse transcription-quantitative polymerase chain reaction (RT-PCR) was undertaken on throat swabs and stool samples. Peripheral blood was taken and serum levels of immunoglobulin IgM and IgG measured. Results showed That, Throat swabs and stool samples tested positive for the nucleic acid of SARS-CoV-Z, but nucleic acid levels were reduced significantly 15 days after disease onset compared with that upon diagnosis. The Ct value of the nucleic acid test was increased significantly. Serum levels of IgM and IgG were significantly higher than those of healthy people. nucleic acid loads in throat swabs and stool samples as well as serum levels of IgM and IgG were highly correlated with the disease course (r = 0.7387,0.5696, -0.546 and 0.6117,respectively, P < 0.05). In this study nucleic acid loads in throat swabs and stool samples as well as serum levels of IgM and IgG are highly correlated with the course of COVID-19.
308067-58-5; adults; antibodies; blood; blood serum; coronavirus disease 2019; disease course; faecal examination; faeces; faeces collection; hospital admission; human diseases; IgG; IgM; nucleic acids; viral diseases; man; Severe acute respiratory syndrome coronavirus 2; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; disease progression; fecal examination; feces; feces collection; SARS-CoV-2; viral infections
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2020
Document Type:
Article
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