The best COVID-19 vaccine: understanding the conundrum behind comparing vaccines

ABSTRACT

Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) infection has created global devastation in the past three years. The Corona Virus Disease-19 (COVID-19) vaccine is the only available resource to fight SARSCoV- 2 infection and its associated complications. As world is trying to recover with the help of vaccines, the change in vaccine development strategy and allowing the usage of vaccines at an emergency level with small size clinical data has created a storm of confusion among many individuals concerning efficiency and efficacy of the vaccine. Though multiple pieces of literature are available regarding the different types and strategies of vaccine development, no paper gives an idea about which vaccine should be used in this emergency. More than 90 vaccine candidates are in the race showing 70-95% efficiency at clinical trials, and still, people are afraid to take vaccines due to lack of awareness. This review compares the available vaccines and evaluates their efficiency based on the available clinical trial results to answer the most frequently asked question of which vaccine is best to be taken at this time?