Alpha-soluble NSF attachment protein prevents the cleavage of the SARS-CoV-2 spike protein by functioning as an interferon-upregulated furin inhibitor
Zhongguo Yufang Shouyi Xuebao / Chinese Journal of Preventive Veterinary Medicine
; 44(3):346-346, 2022.
Article
in English, Chinese
| CAB Abstracts | ID: covidwho-2034493
ABSTRACT
The new coronavirus (SARS-CoV-2) is raging around the world, infecting more than 460 million people and killing more than 6 million people, posing a serious threat to human health. Analyzing the pathogenic mechanism of the virus and discovering new drug targets are the keys to the development of antiviral drugs. Similar to the envelope proteins of many important viruses such as Ebola virus and Marburg virus, the spike (S) protein of SARS-CoV-2 relies on the cleavage and processing of cellular furin to mature during infection, and then make the virus infective, so furin is an important potential target for antiviral therapy. However, the regulation mechanism of furin enzyme activity in cells under physiological and infection conditions is not yet very clear.
Pesticides and Drugs; Control [HH405]; Pesticides and Drugs; Chemistry and Formulation [HH420]; Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Diagnostic, Therapeutic and Pharmacological Biotechnology [WW700]; Biochemistry and Physiology of Microorganisms [ZZ394]; antiviral agents; cells; coronavirus disease 2019; drug development; drug therapy; efficacy; enzyme activity; enzymes; human diseases; interferons; pandemics; potency; viral diseases; viral proteins; zoonoses; man; Severe acute respiratory syndrome coronavirus 2; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; furin; antivirals; chemotherapy; SARS-CoV-2; viral infections; zoonotic infections
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
English
/
Chinese
Journal:
Chinese Journal of Preventive Veterinary Medicine
Year:
2022
Document Type:
Article
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