Your browser doesn't support javascript.
Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt.
Abdelaal, Azza; Abu-Elfatth, Ahmed; Bakkar, Lamees M; El-Azeem, Hanan G Abd; Hetta, Helal F; Badawy, Eman R.
  • Abdelaal A; Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
  • Abu-Elfatth A; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
  • Bakkar LM; Chest Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
  • El-Azeem HGA; Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
  • Hetta HF; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. helalhetta@aun.edu.eg.
  • Badawy ER; Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Infection ; 2022 Sep 22.
Article in English | MEDLINE | ID: covidwho-2321327
ABSTRACT

BACKGROUND:

Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome.

METHODS:

The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, D-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2.

RESULTS:

The results showed significantly higher VWF, D-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher D-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity.

CONCLUSION:

Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. D-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: S15010-022-01917-5

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: S15010-022-01917-5