Humoral immunity induced by mRNA COVID-19 vaccines in Nursing Home Residents previously infected with SARS-CoV-2.
Aging Clin Exp Res
; 34(10): 2577-2584, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-2035473
ABSTRACT
BACKGROUND:
Nursing home (NH) residents suffered the greatest impact of the COVID-19 pandemic. Limited data are available on vaccine-induced immunity and on the protection ensured by a prior infection in this population.AIMS:
The present study aims to monitor antibody levels and their persistence over a 6-month period in NH residents according to the history of prior SARS-CoV-2 infection.METHODS:
We measured anti-trimeric Spike IgG antibody levels in a sample of 395 residents from 25 NHs in 6 Italian Regions at study enrolment (prior to the first dose of vaccine, T0) and then after 2 (T1) and 6 months (T2) following the first vaccine dose. All participants received mRNA vaccines (BNT162b2 or mRNA-1273). Analyses were performed using log-transformed values of antibody concentrations and geometric means (GM) were calculated.RESULTS:
Superior humoral immunity was induced in NH residents with previous SARS-CoV-2 infection. (T0 GM 186.6 vs. 6.1 BAU/ml, p < 0.001; T1 GM 5264.1 vs. 944.4 BAU/ml, p < 0.001; T2 GM 1473.6 vs. 128.7 BAU/ml, p < 0.001). Residents with prior SARS-CoV-2 infection receiving two vaccine doses presented significantly higher antibody concentration at T1 and T2. A longer interval between previous infection and vaccination was associated with a better antibody response over time.DISCUSSION:
In a frail sample of NH residents, prior SARS-CoV-2 infection was associated with a higher humoral response to vaccination. Number of vaccine doses and the interval between infection and vaccination are relevant parameters in determining humoral immunity.CONCLUSIONS:
These findings provide important information to plan future immunization policies and disease prevention strategies in a highly vulnerable population.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Vaccines
/
COVID-19
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Aging Clin Exp Res
Journal subject:
Geriatrics
Year:
2022
Document Type:
Article
Affiliation country:
S40520-022-02239-0
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