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PASC in Solid Organ Transplant Recipients With Self-reported SARS-CoV-2 Infection.
Alasfar, Sami; Chiang, Teresa Po-Yu; Snyder, Andrew J; Ou, Michael T; Boyarsky, Brian J; Abedon, Aura T; Alejo, Jennifer L; Cook, Sydney; Cochran, Willa; Brigham, Emily; Parker, Ann M; Garonzik-Wang, Jacqueline; Massie, Allan B; Brennan, Daniel C; Vannorsdall, Tracy; Segev, Dorry L; Avery, Robin K.
  • Alasfar S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Chiang TP; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Snyder AJ; University of Washington School of Medicine, Seattle, WA.
  • Ou MT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Boyarsky BJ; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Abedon AT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Alejo JL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Cook S; Georgetown University School of Medicine, Washington, DC.
  • Cochran W; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Brigham E; Department of Medicine, University of British Columbia, Vancouver, BC.
  • Parker AM; Vancouver Coastal Health Research Institute, Vancouver, BC.
  • Garonzik-Wang J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Massie AB; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
  • Brennan DC; Department of Surgery, New York University Grossman School of Medicine, New York, NY.
  • Vannorsdall T; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Segev DL; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Avery RK; Department of Surgery, New York University Grossman School of Medicine, New York, NY.
Transplantation ; 2022 Sep 19.
Article in English | MEDLINE | ID: covidwho-2037606
ABSTRACT

BACKGROUND:

Postacute sequelae of SARS-CoV-2 infection (PASC) is an increasingly recognized phenomenon and manifested by long-lasting cognitive, mental, and physical symptoms beyond the acute infection period. We aimed to estimate the frequency of PASC symptoms in solid organ transplant (SOT) recipients and compared their frequency between those with SARS-CoV-2 infection requiring hospitalization and those who did not require hospitalization.

METHODS:

A survey consisting of 7 standardized questionnaires was administered to 111 SOT recipients with history of SARS-CoV-2 infection diagnosed >4 wk before survey administration.

RESULTS:

Median (interquartile range) time from SARS-CoV-2 diagnosis was 167 d (138-221). Hospitalization for SARS-CoV-2 infection was reported in 33 (30%) participants. Symptoms after the COVID episode were perceived as following significant trauma (53%), cognitive decline (50%), fatigue (41%), depression (36%), breathing problems (35%), anxiety (23%), dysgeusia (22%), dysosmia (21%), and pain (19%). Hospitalized patients had poorer median scores in cognition (Quick Dementia Rating System survey score 2.0 versus 0.5, P = 0.02), quality of life (Health-related Quality of Life survey 2.0 versus 1.0, P = 0.015), physical health (Global physical health scale 10.0 versus 11.0, P = 0.005), respiratory status (Breathlessness, Cough and Sputum Scale 1.0 versus 0.0, P = 0.035), and pain (Pain score 3 versus 0 out of 10, P = 0.003). Among patients with infection >6 mo prior, some symptoms were still present as following abnormal breathing (42%), cough (40%), dysosmia (29%), and dysgeusia (34%).

CONCLUSIONS:

SOT recipients reported a high frequency of PASC symptoms. Multidisciplinary approach is needed to care for these patients beyond the acute phase.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: TP.0000000000004340

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: TP.0000000000004340