Diagnosis and management of leptomeningeal disease secondary to grade IV astrocytic glioma.
BMJ Case Rep
; 15(9)2022 Sep 16.
Article
in English
| MEDLINE | ID: covidwho-2038273
ABSTRACT
A man in his mid-40s presented to hospital with confusion, headache and feeling generally unwell. He had had a total resection of a grade IV astrocytic glioma 1 year prior. Initial observations, blood tests and CT head scan were unremarkable for acute features to explain the patient's presentation. However, an MRI head scan on this admission demonstrated a clear communicating hydrocephalus with new abnormal leptomeningeal enhancement, consistent with leptomeningeal metastatic infiltration by glioma. Lumbar puncture cytology and biochemistry supported this interpretation. As a small district general hospital in rural Wales, we discuss the experience of diagnosis and coordination of specialist input from a multidisciplinary team. We share the challenges of managing leptomeningeal disease in the COVID-19 pandemic, in the context of the additional risks this presents with chemotherapy-induced immunosuppression.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Astrocytoma
/
COVID-19
/
Meningeal Neoplasms
/
Antineoplastic Agents
Type of study:
Case report
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
/
Male
Language:
English
Year:
2022
Document Type:
Article
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