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Association between COVID-19 infection and work exposure assessed by the Mat-O-Covid job exposure matrix in the CONSTANCES cohort.
Fadel, Marc; Gilbert, Fabien; Legeay, Clément; Dubée, Vincent; Esquirol, Yolande; Verdun-Esquer, Catherine; Dinh, Aurelien; Sembajwe, Grace; Goldberg, Marcel; Roquelaure, Yves; Leclerc, Annette; Wiernik, Emmanuel; Zins, Marie; Descatha, Alexis.
  • Fadel M; Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Ester Unit, SFR ICAT, CAPTV CDC, Angers, France.
  • Gilbert F; Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Ester Unit, SFR ICAT, CAPTV CDC, Angers, France.
  • Legeay C; Infection Control and Prevention Unit, CHU Angers, Angers, France.
  • Dubée V; Infectious and Tropical Diseases Department, University Hospital CHU Angers, Angers, France.
  • Esquirol Y; Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302/EMR6001, Univ Angers, Nantes Université, INSERM, CNRS, Nantes, France.
  • Verdun-Esquer C; Occupational and Environmental Health Department, CHU, CERPOP UMR 1295, Université Paul Sabatier Toulouse 3, Inserm, Toulouse, France.
  • Dinh A; Service Santé Travail Environnement, INSERM U1219, EPICENE, CHU de Bordeaux, Univ Bordeaux, Bordeaux, France.
  • Sembajwe G; Infectious Disease Unit, Raymond-Poincaré University Hospital, AP-HP (Paris Hospital), Paris Saclay University, Paris, France.
  • Goldberg M; Department of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine, Hofstra/ Northwell, Great Neck, New York, USA.
  • Roquelaure Y; Unité "Cohortes en Population" UMS 011, Inserm/Université de Paris/Université Paris Saclay/UVSQ, Villejuif, France.
  • Leclerc A; Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Ester Unit, SFR ICAT, CAPTV CDC, Angers, France.
  • Wiernik E; Unité "Cohortes en Population" UMS 011, Inserm/Université de Paris/Université Paris Saclay/UVSQ, Villejuif, France.
  • Zins M; Unité "Cohortes en Population" UMS 011, Inserm/Université de Paris/Université Paris Saclay/UVSQ, Villejuif, France.
  • Descatha A; Unité "Cohortes en Population" UMS 011, Inserm/Université de Paris/Université Paris Saclay/UVSQ, Villejuif, France.
Occup Environ Med ; 2022 Sep 20.
Article in English | MEDLINE | ID: covidwho-2038336
ABSTRACT

OBJECTIVES:

The COVID-19 pandemic has brought to light a new occupational health threat. We aimed to evaluate the association between COVID-19 infection and work exposure to SARS-CoV-2 assessed by a job-exposure matrix (JEM), in a large population cohort. We also estimated the population-attributable fraction among exposed subjects.

METHODS:

We used the SAPRIS-SERO sample of the CONSTANCES cohort, limited to subjects actively working, and with a job code available and a questionnaire on extra work activities. The following outcomes were assessed COVID-19 diagnosis was made by a physician; a seropositivity to the ELISA-S test ('serology strict') and ELISA-S test intermediate with positive ELISA-NP or a positive neutralising antibodies SN ('serology large'). Job exposure was assessed using Mat-O-Covid, an expert-based JEM with an Index used as a continuous variable and a threshold at 13/1000.

RESULTS:

The sample included 18 999 subjects with 389 different jobs, 47.7% were men with a mean age of 46.2 years (±9.2 years). The Mat-O-Covid index taken as a continuous variable or with a threshold greater than 13/1000 was associated with all the outcomes in bivariable and multivariable logistic models. ORs were between 1.30 and 1.58, and proportion of COVID-19 attributable to work among exposed participants was between 20% and 40%.

DISCUSSION:

Using the Mat-O-Covid JEM applied to a large population, we found a significant association between work exposure to SARS-CoV-2 and COVID-19 infection, though the estimation of attributable fraction among exposed people remained low to moderate. Further studies during other exposed periods and with other methods are necessary.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2022 Document Type: Article Affiliation country: Oemed-2022-108436

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2022 Document Type: Article Affiliation country: Oemed-2022-108436