Severe fever with thrombocytopenia syndrome virus replicates in brain tissues and damages neurons in newborn mice.
BMC Microbiol
; 22(1): 204, 2022 08 20.
Article
in English
| MEDLINE | ID: covidwho-2038659
ABSTRACT
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne phlebovirus with a high fatality rate of 12-30%, which has an expanding endemic and caused thousands of infections every year. Central nervous system (CNS) manifestations are an important risk factor of SFTS outcome death. Further understanding of the process of how SFTSV invades the brain is critical for developing effective anti-SFTS encephalitis therapeutics. We obeserved changes of viral load in the brain at different time points after intraperitoneal infection of SFTSV in newborn C57/BL6 mice. The virus invaded the brain at 3 h post-infection (hpi). Notably, the viral load increased exponentially after 24 hpi. In addition, it was found that in addition to macrophages, SFTSV infected neurons and replicated in the brain. These findings provide insights into the CNS manifestations of severe SFTS, which may lead to drug development and encephalitis therapeutics.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombocytopenia
/
Phlebovirus
/
Bunyaviridae Infections
/
Encephalitis
/
Severe Fever with Thrombocytopenia Syndrome
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
BMC Microbiol
Journal subject:
Microbiology
Year:
2022
Document Type:
Article
Affiliation country:
S12866-022-02609-8
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