Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria.
Malar J
; 21(1): 255, 2022 Sep 06.
Article
in English
| MEDLINE | ID: covidwho-2038759
ABSTRACT
BACKGROUND:
Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.METHODS:
Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.RESULTS:
The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.CONCLUSION:
Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Malaria, Vivax
/
Malaria, Falciparum
/
Myeloid-Derived Suppressor Cells
/
Malaria
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Malar J
Journal subject:
Tropical Medicine
Year:
2022
Document Type:
Article
Affiliation country:
S12936-022-04268-6
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