Protection of zero-valent iron nanoparticles against sepsis and septic heart failure.
J Nanobiotechnology
; 20(1): 405, 2022 Sep 05.
Article
in English
| MEDLINE | ID: covidwho-2038769
ABSTRACT
BACKGROUND:
Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe in septic cardiomyopathy remain unknown.RESULTS:
NanoFe was prepared via the liquid-phase reduction method and functionalized with the biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed a mouse model of septic myocardial injury by challenging with cecal ligation and puncture (CLP). Our findings demonstrated that nanoFe has a significant protective effect on CLP-induced septic myocardial injury. This may be achieved by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.CONCLUSIONS:
The results provide a theoretical basis for the application strategy and combination of nanoFe in sepsis and septic myocardial injury.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sepsis
/
Nanoparticles
/
Heart Failure
/
Heart Injuries
Limits:
Animals
Language:
English
Journal:
J Nanobiotechnology
Year:
2022
Document Type:
Article
Affiliation country:
S12951-022-01589-1
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