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Effect of invasive mechanical ventilation on the diversity of the pulmonary microbiota.
Liu, Chang; Wu, Kang; Sun, Tianyu; Chen, Bin; Yi, Yaxing; Ren, Ruotong; Xie, Lixin; Xiao, Kun.
  • Liu C; College of Pulmonary & Critical Care Medicine, 8th Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Wu K; School of Medicine, Nankai University, Tianjin, China.
  • Sun T; College of Pulmonary & Critical Care Medicine, 8th Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Chen B; College of Pulmonary & Critical Care Medicine, 8th Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Yi Y; MatriDx Biotechnology Co., Ltd, Hangzhou, China.
  • Ren R; MatriDx Biotechnology Co., Ltd, Hangzhou, China.
  • Xie L; MatriDx Biotechnology Co., Ltd, Hangzhou, China. ruorabbit@163.com.
  • Xiao K; Foshan Branch, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. ruorabbit@163.com.
Crit Care ; 26(1): 252, 2022 08 22.
Article in English | MEDLINE | ID: covidwho-2038845
ABSTRACT
Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (e.g., disease, smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger structural and physiological changes in both tissue and microbiota of lung, due to gastric and oral microaspiration, altered body posture, high O2 inhalation-induced O2 toxicity in hypoxemic patients, impaired airway clearance and ventilator-induced lung injury (VILI), which in turn reduce the diversity of the pulmonary microbiota and may ultimately lead to poor prognosis. Furthermore, changes in (local) O2 concentration can reduce the diversity of the pulmonary microbiota by affecting the local immune microenvironment of lung. In conclusion, systematic literature studies have found that invasive MV reduces pulmonary microbiota diversity, and future rational regulation of pulmonary microbiota diversity by existing or novel clinical tools (e.g., lung probiotics, drugs) may improve the prognosis of invasive MV treatment and lead to more effective treatment of lung diseases with precision.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Microbiota / Lung Type of study: Experimental Studies / Observational study / Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Crit Care Year: 2022 Document Type: Article Affiliation country: S13054-022-04126-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Microbiota / Lung Type of study: Experimental Studies / Observational study / Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Crit Care Year: 2022 Document Type: Article Affiliation country: S13054-022-04126-6