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Immunoinformatics approach to epitope-based vaccine design against the SARS-CoV-2 in Bangladeshi patients.
Akter, Shahina; Shahab, Muhammad; Sarkar, Md Murshed Hasan; Hayat, Chandni; Banu, Tanjina Akhtar; Goswami, Barna; Jahan, Iffat; Osman, Eshrar; Uzzaman, Mohammad Samir; Habib, Md Ahashan; Shaikh, Aftab Ali; Khan, Md Salim.
  • Akter S; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Shahab M; State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
  • Sarkar MMH; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Hayat C; Department of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
  • Banu TA; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Goswami B; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Jahan I; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Osman E; SciTech Consulting and Solutions, Dhaka, Bangladesh.
  • Uzzaman MS; SciTech Consulting and Solutions, Dhaka, Bangladesh.
  • Habib MA; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Shaikh AA; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh.
  • Khan MS; Bangladesh Council of Scientific & Industrial Research (BCSIR), Dhaka, Bangladesh. k2salim@yahoo.com.
J Genet Eng Biotechnol ; 20(1): 136, 2022 Sep 20.
Article in English | MEDLINE | ID: covidwho-2039148
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic which has brought a great challenge to public health. After the first emergence of novel coronavirus SARS-CoV-2 in the city of Wuhan, China, in December 2019. As of March 2020, SARS-CoV-2 was first reported in Bangladesh and since then the country has experienced a steady rise in infections, resulting in 13,355,191 cases and 29,024 deaths as of 27 February 2022. Bioinformatics techniques are used to predict B cell and T cell epitopes from the new SARS-CoV-2 spike glycoprotein in order to build a unique multiple epitope vaccine. The immunogenicity, antigenicity scores, and toxicity of these epitopes were evaluated and chosen based on their capacity to elicit an immune response.

RESULT:

The best multi-epitope of the possible immunogenic property was created by combining epitopes. EAAAK, AAY, and GPGPG linkers were used to connect the epitopes. In several computer-based immune response analyses, this vaccine design was found to be efficient, as well as having high population coverage.

CONCLUSION:

This research is entirely reliant on the development of epitope-based vaccines, and these in silico findings would represent a major step forward in the development of a vaccine that might eradicate SARS-CoV-2 in Bangladeshi patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Journal: J Genet Eng Biotechnol Year: 2022 Document Type: Article Affiliation country: S43141-022-00410-8

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Journal: J Genet Eng Biotechnol Year: 2022 Document Type: Article Affiliation country: S43141-022-00410-8