Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry.
PLoS One
; 17(5): e0267327, 2022.
Article
in English
| MEDLINE | ID: covidwho-2039302
ABSTRACT
OBJECTIVE:
The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear.METHODS:
The Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge.RESULTS:
In the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value < 0.1 by univariate analysis, BMI < 22 kg/m2 (odds ratio (OR) 1.57, 95% confidence interval (CI) 1.11-2.24, P = 0.01), CRP >1.0mg/dL (OR 1.49, 95%CI 1.04-2.14, P = 0.03), and presence of edema at discharge (OR 4.30, 95%CI 2.99-6.22, P<0.001) were associated with an increased risk of appetite loss at discharge, whereas ambulatory status (OR 0.57, 95%CI 0.39-0.83, P = 0.004) and the use of ACE-I/ARB (OR 0.70, 95% CI 0.50-0.98, P = 0.04) were related to a decreased risk in the presence of appetite loss. The cumulative 1-year incidence of all-cause death (primary outcome measure) was significantly higher in patients with appetite loss than in those without appetite loss (31.0% vs. 15.0%, P<0.001). The excess adjusted risk of appetite loss relative to no appetite loss remained significant for all-cause death (hazard ratio (HR) 1.63, 95%CI 1.29-2.07, P<0.001).CONCLUSIONS:
Loss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Patient Discharge
/
Heart Failure
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
PLoS One
Journal subject:
Science
/
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Journal.pone.0267327
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