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Investigation of Possible Factors Influencing the Neutralizing Anti-SARS-CoV-2 Antibody Titer after Six Months from the Second Vaccination Dose in a Sample of Italian Nursing Home Personnel.
Modenese, Alberto; Paduano, Stefania; Bellucci, Rossana; Marchetti, Simona; Bruno, Fulvio; Grazioli, Pietro; Vivoli, Roberto; Gobba, Fabriziomaria; Bargellini, Annalisa.
  • Modenese A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.
  • Paduano S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.
  • Bellucci R; Laboratorio Analisi TEST SrL, 41121 Modena, Italy.
  • Marchetti S; Laboratorio Analisi TEST SrL, 41121 Modena, Italy.
  • Bruno F; Fondazione Scarpari Forattini Onlus, 46020 Schivenoglia, Italy.
  • Grazioli P; Fondazione Scarpari Forattini Onlus, 46020 Schivenoglia, Italy.
  • Vivoli R; Laboratorio Analisi TEST SrL, 41121 Modena, Italy.
  • Gobba F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.
  • Bargellini A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, Italy.
Antibodies (Basel) ; 11(3)2022 Sep 19.
Article in English | MEDLINE | ID: covidwho-2039761
ABSTRACT
The titer of the anti-SARS-CoV-2 antibodies produced after vaccination shows a relevant decay over time, as demonstrated in several studies. However, less is known on the possible factors affecting the entity of this decay. The aim of this study is to analyze a group of individual factors which are possibly associated with anti-SARS-CoV-2 antibody titer decay six months after the second vaccine dose. We report here the results of a follow-up serological analysis and a questionnaire-based evaluation of a sample of workers from an Italian nursing home, vaccinated with two doses of BNT162b2 vaccine in early 2021. The baseline data were collected one month after the vaccine, while in the present analysis we report the data collected six months later. Our data show a relevant decay of the neutralizing antibody titer, even if for all the workers a largely positive response was detected. Moreover, our results demonstrate a possible association between younger age and the absence of previous COVID-19 infection, and a higher decay rate of the anti-SARS-CoV-2 antibodies titer.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Antib11030059

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Antib11030059