Vertical transmission of COVID-19 can cause subsequent complications in pregnancy

ABSTRACT

Vertical transmission of acute respiratory syndrome involving coronavirus-2 in pregnant women with COVID-19 (serious acute respiratory syndrome, coronavirus-2 [SARS-CoV-2]) and variations in the progression of maternity complications, including abortion, fetal malformations, impaired fetal development, and/or stillbirth. According to the clinical literature, vertical transmission of SARS-CoV-2 is rare, but even if a SARS-CoV-2-negative neonatal test is administered, there is still a risk of infection and persistent abnormalities including fetal and maternal vascular dysfunction, major SARS-CoV-2 receptors are known to be an enzyme converting to angiotensin 2 (ACE2) and are highly expressed in maternal fever cells. Endothelial cells, smooth muscle vascular primary and secondary chorionic cells. However, it is not possible to eliminate other routes of placental infection. CoV-2 is often contaminated by fusion trophoblasts, but fetuses are seldom affected. The existence of the placental barrier is suggested by these findings, even if it is not fully successful. Intensive health research, such as repeated ultrasonography and fetal heart rate tracking, is strongly advised during pregnancy. Women infected with COVID-19 can carefully evaluate placental specimens after delivery through morphological and molecular techniques, as the extent and molecular mechanisms of intrauterine vertical transmission of SARS-CoV-2 are yet to be established. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.