True mycotic aneurysms: a report of three patients with internal carotid artery aneurysm and mucormycosis and literature review
Shiraz E Medical Journal
; 23(9), 2022.
Article
in English
| CAB Abstracts | ID: covidwho-2040313
ABSTRACT
Introduction:
Aneurysm formation of internal carotid arteries (ICA) in patients with mucormycosis is a scarce phenomenon. However, the prevalence of rhino-cerebral mucormycosis has been reported to increase after the Coronavirus disease 2019 (COVID-19) pandemic. Case Presentation Three patients with stroke and subarachnoid hemorrhage presented due to ICA aneurysm after the involvement of adjacent paranasal sinuses (PNS) with mucormycosis. They had a history of diabetes and corticosteroid use. Also, one of them was treated with imatinib. Two out of the three patients were infected with SARS-CoV-2 before developing mucormycosis. Two patients had diagnostic angiography before endovascular intervention. One patient did not undergo any therapeutic intervention due to total artery occlusion, whereas the other patient experienced a successful parent artery occlusion by coiling and only survived this patient. Although all patients received antifungal treatment and surgical debridement, two of them died.Conclusions:
In patients with rhino-cerebral mucormycosis, aneurysm evolution should be promptly and meticulously investigated by Magnetic Resonance Angiography (MRA) and Computed Tomography Angiography (CTA). As this type of aneurysm is very fast-growing, as soon as the involvement of the sphenoid sinus is detected, the possibility of ICA aneurysm formation should always be kept in mind. If the patient develops an aneurysm, prompt intensive antifungal therapy and therapeutic endovascular interventions such as stenting, coiling, or sacrificing should be considered as soon as possible to optimize outcomes.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Non-drug Therapy and Prophylaxis of Humans [VV710]; Non-communicable Human Diseases and Injuries [VV600]; Pesticides and Drugs; Control [HH405]; aneurysm; human diseases; mycoses; mucormycosis; corticoids; drug therapy; medical treatment; antifungal agents; viral diseases; coronavirus disease 2019; blood sugar; blood vessels; case reports; clinical aspects; diabetes mellitus; disease course; disease incidence; disease prevalence; epidemiology; infections; man; Severe acute respiratory syndrome coronavirus 2; Mucorales; Iran; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Mucoromycotina; Zygomycota; fungi; high Human Development Index countries; lower-middle income countries; Middle East; West Asia; Asia; imatinib; SARS-CoV-2; corticosteroids; chemotherapy; fungistats; viral infections; blood glucose; glucose in blood; clinical picture; disease progression
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Reviews
Language:
English
Journal:
Shiraz E Medical Journal
Year:
2022
Document Type:
Article
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