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Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases.
Mitsumura, Takahiro; Okamoto, Tsukasa; Tosaka, Mizuho; Yamana, Takashi; Shimada, Sho; Iijima, Yuki; Sakakibara, Rie; Shibata, Sho; Honda, Takayuki; Shirai, Tsuyoshi; Ishizuka, Masahiro; Aiboshi, Junichi; Furusawa, Haruhiko; Tateishi, Tomoya; Tamaoka, Meiyo; Shigemitsu, Hidenobu; Arai, Hirokuni; Otomo, Yasuhiro; Tohda, Shuji; Anzai, Tatsuhiko; Takahashi, Kunihiko; Yasuda, Shinsuke; Miyazaki, Yasunari.
  • Mitsumura T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Okamoto T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Tosaka M; Department of Pulmonary Immunotherapeutics, Tokyo Medical and Dental University, Japan.
  • Yamana T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Shimada S; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Iijima Y; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Sakakibara R; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Shibata S; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Honda T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Shirai T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Ishizuka M; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Aiboshi J; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Furusawa H; Trauma and Acute Critical Care Center, Tokyo Medical and Dental University, Japan.
  • Tateishi T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Tamaoka M; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Shigemitsu H; Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
  • Arai H; Department of Intensive Care Medicine, Tokyo Medical and Dental University, Japan.
  • Otomo Y; Department of Cardiovascular Surgery, Tokyo Medical and Dental University, Japan.
  • Tohda S; Trauma and Acute Critical Care Center, Tokyo Medical and Dental University, Japan.
  • Anzai T; Department of Laboratory Medicine, Tokyo Medical and Dental University, Japan.
  • Takahashi K; Department of Biostatistics, M&D Data Science Center, Tokyo Medical and Dental University, Japan.
  • Yasuda S; Department of Biostatistics, M&D Data Science Center, Tokyo Medical and Dental University, Japan.
  • Miyazaki Y; Department of Rheumatology, Tokyo Medical and Dental University, Japan.
Jpn J Infect Dis ; 75(5): 504-510, 2022 Sep 22.
Article in English | MEDLINE | ID: covidwho-2040400
ABSTRACT
Factors associated with mortality are important in the treatment of coronavirus disease 2019 (COVID-19). Polymerase chain reaction (PCR) is the gold standard for diagnosing COVID-19, which reflects the viral load in the upper respiratory tract. In total, 523 patients were enrolled in this study; of them, 441 and 75 patients underwent PCR testing of nasopharyngeal swabs and sputum samples, respectively, within 20 days from onset of COVID-19. We investigated the association between RNA copy number and the COVID-19 severity and mortality rate and its effect on the predictive performance for severity and mortality. RNA copy numbers in nasopharyngeal swabs were higher in the non-survivor group than in the survivor group. Multivariate logistic regression analysis identified that the high RNA copy number (≥9 log10 /swab) in nasopharyngeal swabs was a factor associated with mortality (odds ratio, 4.50; 95% confidence interval, 1.510-13.100; P = 0.008). Furthermore, adding RNA copy number (≥9 log10 /swab) in severe cases, adjusted by duration from onset to PCR, improved mortality predictive performance based on known factors. The RNA copy number is a factor associated with the mortality of patients with COVID-19 and can improve the predictive performance of mortality in severe cases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Jpn J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Yoken.JJID.2022.080

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Jpn J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Yoken.JJID.2022.080