S Protein of SARS-CoV-2: research progress and challenges

ABSTRACT

SARS-CoV-2, which caused a pandemic, is a new coronavirus pathogen that can spread rapidly from person to person. The spike protein (S) on the surface of coronavirus plays an important role in determining the host specificity. pathogenicity and interspecies transmission of the virus. S protein is the most studied SARS - CoV-2 protein after the outbreak of SARS-CoV-2. S protein is also the most important antigenic protein for the development of SAES - CoV -2 vaccine and the important target of antiviral drugs. Here the latest research progress of SARS-CoV-2 S protein was reviewed, and the problems and challenges in current research were discussed. .