Advances in the application of CRISPR-Cas system for SARS-CoV-2 diagnostic test

ABSTRACT

The outbreak of coronavirus disease 2019（COVID-19）, caused by severe acute respiratory syndrome coronavirus（SARS-CoV-2） at the end of 2019, results in a global rapid pandemic.The emerging infectious disease is life threaten and profoundly undermines the normal operation all over the world.Rapid and accurate detection of SARS-CoV-2 is an essential component of efforts to combat SARS-CoV-2 spread.Although many technologies for SARS-CoV-2 detection have been commercialized and have played a role in the control of COVID-19 epidemic to some extent yet, each of them is still with certain limitations.Recently, increasing number of teams attempt to detect SARS-CoV-2 by CRISPR-Cas（clustered regularly interspaced short palindromic repeats-Cas） system.With excellent specificity and sensitivity, it has been believed to be a potential technology in COVID-19 diagnosis and therapy.The review provides an overview of CRISPR-Cas system for SARS-CoV-2 detection and COVID-19 therapy, along with its clinical translation potential.Hope it has some referential significance for the control of SARS-CoV-2 spread and COVID-19 epidemic.