SARS-CoV2 infection in oncohematological patients admitted to a general hospital
Swiss Medical Weekly
; 152:32S, 2022.
Article
in English
| EMBASE | ID: covidwho-2040833
ABSTRACT
Introduction:
Oncohematological patients (OHP) with Covid19 (C19) can develop serious and lethal complications. It depends on underlying disease, chemotherapy (ChT) and immunosuppressor (IS) prescribed.Objectives:
compare mortality (M) in OHP vs. hospitalized normal hosts (NH);analyze independent risk factors (IRFs) of M.Methods:
3/2020-5/2022;population OHP with C19. Prospective, observational data collection. Clinical presentation NIH scale;Active treatment (AT) IS or ChT;Complete C19 vaccination (CV). Statistics ANOVA and Tukey's post hoc tests for comparison of groups. Multivariate test to analyze IRFs associated with M.Results:
OHP 62;MM 19.3%;LLC 21%;Lymphomas 24.2%;ALL 11.3%;AML 9.7%;MDS 14.5%. Age 68 (17-88);Male sex 77.4%;moderate CAP 72.6%;Severe CAP 27.4%;CV 22.6%;neutropenia (NP) 22.6%;AT 61.3%. MM was associated with higher M. OD 5.3 (95% CI 1.1742 -24.1685). OH had higher M statistically significant difference (SSD)- vs. ICP (12/62) 19% vs. (118/1168) 10%;p 0.02. Multivariate analysis adjusted for age and sex MM (OR 5.32, 95% CI 1.1742-24.1685) and Severe CAP (OD 11.23, 95% CI 2.0636 - 61.1310) were IRFs associated with M. AT (OR 3.2) and NP (OR 4.18) had higher risk of M with nonSSD;CV (OR 0.66 95% CI 0.1110-4.0235) had lower risk without SSD.Conclusions:
MM and severe CAP were IRFs for M. CAP was associated with higher M in OHP than NH. CV could be a protective factor without SSD. The high M documented in OHP with C19 justifies implementation of early preventive measures and treatment in this population.
immunosuppressive agent; unclassified drug; adult; analysis of variance; cancer chemotherapy; cancer patient; community acquired pneumonia; conference abstract; controlled study; coronavirus disease 2019; drug therapy; female; general hospital; human; lymphoma; major clinical study; male; neutropenia; post hoc analysis; prevention; risk factor; vaccination
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Swiss Medical Weekly
Year:
2022
Document Type:
Article
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