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Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus.
Kim, Dong-Hwi; Han, Sang-Hoon; Go, Hyeon-Jeong; Kim, Da-Yoon; Kim, Jae-Hyeong; Lee, Joong-Bok; Park, Seung-Yong; Song, Chang-Seon; Lee, Sang-Won; Choi, In-Soo.
  • Kim DH; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Han SH; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Go HJ; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Kim DY; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Kim JH; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Lee JB; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Park SY; KU Center for Animal Blood Medical Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.
  • Song CS; Konkuk University Zoonotic Diseases Research Center, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.
  • Lee SW; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
  • Choi IS; KU Center for Animal Blood Medical Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.
Vet Res Commun ; 46(4): 1363-1368, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2041311
ABSTRACT
Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. In this study, we aimed to investigate the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. Our results suggest that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parvovirus, Canine / Coronavirus, Canine / Adenoviridae Infections / Parvoviridae Infections / Distemper / Distemper Virus, Canine / Dog Diseases Limits: Animals Language: English Journal: Vet Res Commun Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parvovirus, Canine / Coronavirus, Canine / Adenoviridae Infections / Parvoviridae Infections / Distemper / Distemper Virus, Canine / Dog Diseases Limits: Animals Language: English Journal: Vet Res Commun Year: 2022 Document Type: Article