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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern.
Sun, Peifang; Ramos, Irene; Coelho, Camila H; Grifoni, Alba; Balinsky, Corey A; Vangeti, Sindhu; Tarke, Alison; Bloom, Nathaniel I; Jani, Vihasi; Jakubski, Silvia J; Boulifard, David A; Cooper, Elizabeth; Goforth, Carl W; Marayag, Jan; Marrone, Amethyst; Nunez, Edgar; White, Lindsey; Porter, Chad K; Sugiharto, Victor A; Schilling, Megan; Mahajan, Avinash S; Beckett, Charmagne; Sette, Alessandro; Sealfon, Stuart C; Crotty, Shane; Letizia, Andrew G.
  • Sun P; Naval Medical Research Center, Silver Spring, MD, USA.
  • Ramos I; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Coelho CH; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Grifoni A; La Jolla Institute for Immunology, La Jolla, CA, USA.
  • Balinsky CA; La Jolla Institute for Immunology, La Jolla, CA, USA.
  • Vangeti S; Naval Medical Research Center, Silver Spring, MD, USA.
  • Tarke A; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Bloom NI; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jani V; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jakubski SJ; Stockholm University, Stockholm, Sweden.
  • Boulifard DA; La Jolla Institute for Immunology, La Jolla, CA, USA.
  • Cooper E; La Jolla Institute for Immunology, La Jolla, CA, USA.
  • Goforth CW; Naval Medical Research Center, Silver Spring, MD, USA.
  • Marayag J; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Marrone A; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Nunez E; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • White L; Naval Medical Research Center, Silver Spring, MD, USA.
  • Porter CK; Naval Medical Research Center, Silver Spring, MD, USA.
  • Sugiharto VA; Navy Medicine Readiness and Training Command, Jacksonville, FL, USA.
  • Schilling M; Naval Medical Research Center, Silver Spring, MD, USA.
  • Mahajan AS; Naval Medical Research Center, Silver Spring, MD, USA.
  • Beckett C; Naval Medical Research Center, Silver Spring, MD, USA.
  • Sette A; Naval Medical Research Center, Silver Spring, MD, USA.
  • Sealfon SC; Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
  • Crotty S; Naval Medical Research Center, Silver Spring, MD, USA.
  • Letizia AG; Naval Medical Research Center, Silver Spring, MD, USA.
iScience ; 25(10): 105202, 2022 Oct 21.
Article in English | MEDLINE | ID: covidwho-2041844
ABSTRACT
The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105202

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105202