Safety of and antibody response to the BNT162b2 COVID-19 vaccine in adolescents and young adults with underlying disease
J Infect Chemother
; 2022.
Article
in English
| ScienceDirect | ID: covidwho-2041941
ABSTRACT
BACKGROUND:
Data are limited regarding the safety of and antibody response to the BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger ribonucleic acid vaccine in adolescents and young adults with underlying disease.METHODS:
This prospective observational study enrolled patients age 12-25 years with chronic underlying disease who received 2 doses of BNT162b2. A 19-item questionnaire was used to assess adverse events within 7 days post-vaccination, and data regarding severe adverse events were collected from electronic medical records. An antibody titer for the receptor-binding domain of the spike protein in SARS-CoV-2 was used to assess antibody response after the second vaccine dose.RESULTS:
Study participants were 429 patients (241 [56%] age 12-15 years;188 [43.8%] age 16-25 years). The most common underlying diseases were genetic or chromosomal abnormalities and/or congenital anomalies, followed by endocrine or metabolic diseases;33% of participants were immunocompromised. Severe adverse events were observed after the second dose in 1 (0.4%) patient age 12-15 years and in 2 (1.1%) patients age 16-25 years;all patients recovered. Seropositivity after the second vaccine dose was 99.0%. The geometric mean antibody titer was higher in patients age 12-15 years versus 16-25 years (1603.3 [1321.8-1944.7] U/mL vs. 949.4 [744.2-1211.0] U/mL). Compared with immunocompetent patients, immunocompromised patients had a lower antibody titer (2106.8 [1917.5-2314.7] U/mL vs. 467.9 [324.4-674.8] U/mL).CONCLUSIONS:
Vaccination with BNT162b2 was acceptably safe and immunogenic for adolescents and young adults with underlying disease.
Full text:
Available
Collection:
Databases of international organizations
Database:
ScienceDirect
Topics:
Vaccines
Language:
English
Journal:
J Infect Chemother
Year:
2022
Document Type:
Article
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