Cuban Abdala vaccine: Effectiveness in preventing severe disease and death from COVID-19 in Havana, Cuba; A cohort study.
Lancet Reg Health Am
; 16: 100366, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-2042000
ABSTRACT
Background:
COVID-19 vaccines have proven safe and efficacious in reducing severe illness and death. Cuban protein subunit vaccine Abdala has shown safety, tolerability and efficacy (92·3% [95% CI 85·7â95·8]) against SARS-CoV-2 in clinical trials. This study aimed to estimate Abdala's real-world vaccine effectiveness (VE).Methods:
This retrospective cohort study in Havana analyzed Cuban Ministry of Public Health databases (May 12-August 31, 2021) to assess VE in preventing severe illness and death from COVID-19 (primary outcomes). Cox models accounting for time-varying vaccination status and adjusting by demographics were used to estimate hazard ratios. A subgroup analysis by age group and a sensitivity analysis including a subgroup of tested persons (qRT-PCR) were conducted. Daily cases and deaths were modelled accounting for different VE.Findings:
The study included 1 355 638 persons (Mean age 49·5 years [SD 18·2]; 704 932 female [52·0%]; ethnicity data unavailable) 1 324 vaccinated (partially/fully) and 31 433 unvaccinated. Estimated VE against severe illness was 93·3% (95% CI 92·1-94·3) in partially- vaccinated and 98·2% (95% CI 97·9-98·5) in fully-vaccinated and against death was 94·1% (95% CI 92·5-95·4) in partially-vaccinated and 98·7% (95% CI 98·3-99·0) in fully-vaccinated. VE exceeded 92·0% in all age groups. Daily cases and deaths during the study period corresponded to a VE above 90%, as predicted by models.Interpretation:
The Cuban Abdala protein subunit vaccine was highly effective in preventing severe illness and death from COVID-19 under real-life conditions.Funding:
Cuban Ministry of Public Health. Genetic Engineering and Biotechnology Centre.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Country/Region as subject:
Cuba
Language:
English
Journal:
Lancet Reg Health Am
Year:
2022
Document Type:
Article
Affiliation country:
J.lana.2022.100366
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