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Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors.
Hetland, Geir; Fagerhol, Magne Kristoffer; Dimova-Svetoslavova, Veselka Petrova; Mirlashari, Mohammad Reza; Nguyen, Nhan Trung; Lind, Andreas; Kolset, Svein Olav; Søraas, Arne Vasli Lund; Nissen-Meyer, Lise Sofie Haug.
  • Hetland G; Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
  • Fagerhol MK; Department of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Dimova-Svetoslavova VP; Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
  • Mirlashari MR; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
  • Nguyen NT; Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
  • Lind A; Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
  • Kolset SO; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
  • Søraas AVL; Department of Nutrician, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Nissen-Meyer LSH; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
Scand J Clin Lab Invest ; 82(6): 481-485, 2022 10.
Article in English | MEDLINE | ID: covidwho-2042400
ABSTRACT
Persisting inflammation has been discovered in lungs and other parenchymatous organs of some COVID-19 convalescents. Calprotectin, neutrophil extracellular traps (NETs), syndecan-1 and neopterin are general key inflammatory markers, and systemically enhanced levels of them may remain after the COVID-19 infection. These inflammatory markers were therefore measured in serum samples of 129 COVID-19 convalescent and 27 healthy blood donors or employees at Oslo Blood bank, Norway. Also antibodies against SARS-CoV-2 nucleocapsid antigen were measured, and timing of sampling and severity of infection noted. Whereas neopterin and NETs values remained low and those for syndecan-1 were not raised to statistically significant level, concentrations for calprotectin, as measured by a novel mixed monoclonal assay, were significantly increased in the convalescents. Antibodies against SARS-CoV-2 nucleocapsid antigen were elevated, but did not correlate with levels of inflammatory markers. Difference between the groups in only one biomarker makes evaluation of ongoing or residual inflammation in the convalescents difficult. If there is a low-grade inflammation, it would in that case involve neutrophils.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Scand J Clin Lab Invest Year: 2022 Document Type: Article Affiliation country: 00365513.2022.2123387

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Scand J Clin Lab Invest Year: 2022 Document Type: Article Affiliation country: 00365513.2022.2123387