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Steroids Therapy in Patients With Severe COVID-19: Association With Decreasing of Pneumonia Fibrotic Tissue Volume.
He, Jin-Wei; Su, Ying; Qiu, Ze-Song; Wu, Jiang-Jie; Chen, Jun; Luo, Zhe; Zhang, Yuyao.
  • He JW; School of Information Science and Technology, ShanghaiTech University, Shanghai, China.
  • Su Y; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Qiu ZS; School of Information Science and Technology, ShanghaiTech University, Shanghai, China.
  • Wu JJ; School of Information Science and Technology, ShanghaiTech University, Shanghai, China.
  • Chen J; Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Luo Z; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Zhang Y; School of Information Science and Technology, ShanghaiTech University, Shanghai, China.
Front Med (Lausanne) ; 9: 907727, 2022.
Article in English | MEDLINE | ID: covidwho-2043474
ABSTRACT

Background:

We use longitudinal chest CT images to explore the effect of steroids therapy in COVID-19 pneumonia which caused pulmonary lesion progression. Materials and

Methods:

We retrospectively enrolled 78 patients with severe to critical COVID-19 pneumonia, among which 25 patients (32.1%) who received steroid therapy. Patients were further divided into two groups with severe and significant-severe illness based on clinical symptoms. Serial longitudinal chest CT scans were performed for each patient. Lung tissue was segmented into the five lung lobes and mapped into the five pulmonary tissue type categories based on Hounsfield unit value. The volume changes of normal tissue and pneumonia fibrotic tissue in the entire lung and each five lung lobes were the primary outcomes. In addition, this study calculated the changing percentage of tissue volume relative to baseline value to directly demonstrate the disease progress.

Results:

Steroid therapy was associated with the decrease of pneumonia fibrotic tissue (PFT) volume proportion. For example, after four CT cycles of treatment, the volume reduction percentage of PFT in the entire lung was -59.79[±12.4]% for the steroid-treated patients with severe illness, and its p-value was 0.000 compared to that (-27.54[±85.81]%) in non-steroid-treated ones. However, for the patient with a significant-severe illness, PFT reduction in steroid-treated patients was -41.92[±52.26]%, showing a 0.275 p-value compared to -37.18[±76.49]% in non-steroid-treated ones. The PFT evolution analysis in different lung lobes indicated consistent findings as well.

Conclusion:

Steroid therapy showed a positive effect on the COVID-19 recovery, and its effect was related to the disease severity.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.907727

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.907727