Your browser doesn't support javascript.
Diagnostic Efficacy of CT Examination on Early Detection of Lung Cancer during Pandemic of COVID-19.
Zhao, Yanjie; Wang, Ruibin; Shi, Feng; Wu, Jiangping; Jiang, Fusheng; Song, Qingkun.
  • Zhao Y; Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Wang R; Department of Emergency, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Shi F; Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Wu J; Department of Cancer Research, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Jiang F; Department of Thoracic Surgery, Beijing Shijitan Hospital, Capital Medical University, Tieyi Road 10, Haidian District, Beijing 100038, China.
  • Song Q; Department of Clinical Epidemiology, Beijing Youan Hospital, Capital Medical Univerisity, Youanmenwai Xitoutiao 8, Fengtai District, Beijing 100069, China.
Diagnostics (Basel) ; 12(10)2022 Sep 26.
Article in English | MEDLINE | ID: covidwho-2043625
ABSTRACT

BACKGROUND:

Since the outbreak of COVID-19 in 2020, routine CT examination was recommended to hospitalized patients at some hospitals and discovered lung cancer patients at an early stage. This study aimed to investigate the detection efficacy of routine CT examination on early diagnosis of lung cancer, especially on pathological characteristics.

METHODS:

The epidemic of COVID-19 outbreak in January 2020 in China, and routine CT examination was recommended to hospitalized patients in June 2020 and ended in July 2021. Based on the time points, we compared the diagnosis efficacy between three periods pre-period, peri-period, and the period of routine CT examination.

RESULTS:

During the period of routine CT examination, more early stages of lung cancer were detected and the tumor size was reduced to 2.14 cm from 3.21 cm at pre-period (p = 0.03). The proportion of lung adenocarcinoma and early stage adenocarcinoma was increased by 12% and 30% in the period of routine CT examination, with referral to the pre-period of CT examination (p < 0.05). A total of 61% of diagnosed patients had the wild type of TP53 gene during the period of routine CT examination, compared to 45% of patients at the pre-period of CT examination (p = 0.001). The median Ki-67 index was 15% among patients diagnosed at the period of routine CT examination and increased to 35% at the pre-period of CT examination (p < 0.001). The period of routine CT examination was associated with a 78% higher probability of detecting an early stage of adenocarcinoma (OR = 1.78, 95%CI 1.03, 3.08) but no significant association was observed for squamous cell carcinoma. From the pre-period to the period of routine CT examination, the proportion of female patients and non-smoking patients increased by 57% and 44%, respectively (p < 0.001).

CONCLUSION:

Routine CT examination could detect more lung cancer at an early stage, especially for adenocarcinoma, and detect patients with less aggressive features. Further studies were warranted to confirm the findings.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12102317

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12102317