The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial.
Int J Environ Res Public Health
; 19(18)2022 Sep 19.
Article
in English
| MEDLINE | ID: covidwho-2043691
ABSTRACT
The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. METHODS:
The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups Group (GP) 1 received charcoal capsules as a control group, and GP 2 received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3 received three capsules of whole Nigella sativa seeds every 12 h, GP 4 received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5 received one capsule of Nigella sativa powder every 12 h; GP 6 received two capsules of Nigella sativa powder every 12 h; GP 7 received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions.RESULTS:
262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6.CONCLUSIONS:
The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biological Products
/
Nigella sativa
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Traditional medicine
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijerph191811798
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