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Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report.
Iannuzzi, Arcangelo; Parrella, Antonio; De Ritis, Francesca; Cammarota, Anna; Berloco, Lucia; Paudice, Francesca; D'Angelo, Giovanni; Aliberti, Emilio; Iannuzzo, Gabriella.
  • Iannuzzi A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Parrella A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • De Ritis F; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Cammarota A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Berloco L; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Paudice F; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • D'Angelo G; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
  • Aliberti E; Department of Acute Internal Medicine, Royal Victoria Infirmary, Newcastle NE1 4LP, UK.
  • Iannuzzo G; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
Medicina (Kaunas) ; 58(9)2022 Sep 15.
Article in English | MEDLINE | ID: covidwho-2043856
ABSTRACT
During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / COVID-19 / Hemoglobinuria, Paroxysmal / Anemia, Aplastic Type of study: Case report / Diagnostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Medicina58091282

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / COVID-19 / Hemoglobinuria, Paroxysmal / Anemia, Aplastic Type of study: Case report / Diagnostic study Topics: Long Covid Limits: Aged / Female / Humans Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Medicina58091282